ABSTRACT
Metabolic disorders are some of the major sources of complications in the body. About 1.7 million people worldwide have obesity-related problems that include hyperglycaemia; dyslipidaemia and haemostatic defects. The purpose of the study was to determine the association of elevated Factor VII (FVII) activity with hyperglycaemia; dyslipidaemia and obesity in a rural black population living in Ga-Mothapo village. This cross-sectional study consisted of 286 females and 96 males aged 18-65 years. Fasting blood samples were analysed for glucose; triglycerides; total cholesterol; high density lipoprotein cholesterol (HDL-C) and FVII. Low density lipoprotein cholesterol (LDL-C) was calculated from total cholesterol; triglycerides and HDL-C using the Friedewald formula. Weight and height were measured using a weighing scale and the Seca telescopic height-measuring rod; respectively. Body mass index was calculated from weight and height. Statistical analysis was done using Statistical Package for Social Sciences version 21.0. The following results were obtained: correlation between elevated FVII activity and hyperglycaemia (p=0.000); hypercholesterolaemia (p=0.000); LDL-C (p=0.000); obesity (p=0.000); hypertriglyceridaemia (p=0.572) and low HDL-C (p=0.201). In conclusion; elevated FVII activity was found to be significantly associated with hyperglycaemia; hypercholesterolaemia; high LDL-C and obesity. The association with hypertriglyceridaemia and a low HDL-C level was not significant